Surgery is needed to prevent the closing of sutures in the skull from damaging brain development. Combined orthodontic and orthognathic surgery can help to relieve some of the facial deformities, such as the flat or concave face. In particular, the LeFort III, a surgical procedure, can be used to detach the midface from the rest of the skull to reposition it appropriately. Additionally, aggressive surgery is needed to separate as many fingers and toes as possible in life. As of yet, there is no way to separate bones of the hands and fingers once the fusion has taken place.
